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We analyzed data from all COVID-19 case reports to collect information on age, sex, co-morbidities, clinical course and outcomes, treatments received, and complications that occurred. The aggregate data set included 85,928 cases that met the inclusion criteria of the Journal of the American Medical Association (JAMA) publication [56]. Twenty-three percent of patient reports in our data set were missing inclusion criteria and those records were excluded from further analysis. Records within the data set predominantly reported on patients presented with fever, cough, and shortness of breath and were reported to be hospitalized. Less than half of the data were reported in nosocomial case series, indicating that the majority of patient reports were reported in the community setting.
SARS-CoV-2 infections have a higher mortality among older adults (age >55 years) and those with underlying conditions such as cardiopulmonary disease. However, after intravenous corticosteroid, investigators report that viral clearance is not associated with improved clinical outcomes [16]. Inflammatory cytokine release syndrome (CRS) or macrophage activation syndrome (MAS) is reported in severe cases and can be life-threatening. In some cases of severe CRS/MAS, a reduction in steroids is associated with worsening of clinical status and/or the requirement for ventilator support. The etiologic trigger of MAS remains unknown. MAS has been associated with SARS-CoV and MERS-CoV infection [1, 2]. 7211a4ac4a
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