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The study aimed to describe the prevalence and clinical characteristics of subclinical pulmonary arterial hypertension (PAH) in patients with cardiac allograft vasculopathy (CAV) treated with the mammalian target of rapamycin (mTOR) inhibitor sirolimus (SRL). All adult patients with heart transplantation (HTx) performed at the University Hospital of Geneva, Switzerland were screened for pulmonary capillary wedge pressure (PCWP > 15 mmHg at echocardiography [echo]) in the month following HTx. Patients with PCWP > 15 mmHg, but without known disease, were offered a transthoracic echo to assess for the presence of pulmonary hypertension (PH). Measurement of pulmonary arterial systolic pressure (PASP) and determination of the right ventricular to left ventricular ratio (RV/LV) > 1.0 were considered to be indicative of subclinical PH. Thirty-eight of 84 (45%) patients with HTx and PAH following SRL for CAV had elevated PCWP (mean: 19.2 ± 6.5 mmHg, median 20, IQR 15-27). PH was more frequently associated with elevated creatinine (41% vs. 12%, p Cadmium-related deformities in the radiolucency of the calcaneus 0b46394aab